Registered Nurses Salary in South Carolina

Registered nurses in South Carolina earn the most in Florence (average $100,700 a year) and the least in Hilton Head Island ($82,270), across the 8 South Carolina metro areas we cover. Statewide, BLS puts the registered nurses average at $87,670 and the median at $82,360 for 49,750 workers. The U.S. average for this job is $101,420.

Registered Nurses average salary by city in South Carolina

Florence$100,700
Charleston$91,710
Columbia$88,030
Greenville$85,030
Sumter$84,470
Spartanburg$84,020
Myrtle Beach$82,860
Hilton Head Island$82,270

Pay, take-home pay and cost of living

City	Average	Median	25th pct.	Take-home*	Cost of living
Florence	$100,700	$81,170	$66,860	$75,392	87
Charleston	$91,710	$92,800	$78,260	$69,583	101
Columbia	$88,030	$81,920	$75,940	$67,238	94
Greenville	$85,030	$81,400	$78,060	$65,326	93
Sumter	$84,470	$86,260	$72,710	$64,970	88
Spartanburg	$84,020	$82,360	$70,250	$64,683	91
Myrtle Beach	$82,860	$80,640	$76,510	$63,944	94
Hilton Head Island	$82,270	$81,400	$67,180	$63,568	98

*Average salary after federal and state taxes for a single filer. Cost of living: BEA price parity, U.S. = 100.

Registered Nurses salary in other states

Registered Nurses salary by city and state

More about pay in South Carolina

Sources and how to read this page

Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1141.
U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.

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