Medical Assistants Salary in South Dakota

Medical assistants in South Dakota earn the most in Sioux Falls (average $43,390 a year) and the least in Rapid City ($41,390), across the 2 South Dakota metro areas we cover. Statewide, BLS puts the medical assistants average at $42,170 and the median at $41,870 for 1,340 workers. The U.S. average for this job is $46,120.

Medical Assistants average salary by city in South Dakota

Sioux Falls$43,390
Rapid City$41,390

Pay, take-home pay and cost of living

City	Average	Median	25th pct.	Take-home*	Cost of living
Sioux Falls	$43,390	$43,760	$38,380	$37,044	91
Rapid City	$41,390	$40,690	$36,190	$35,437	89

*Average salary after federal and state taxes for a single filer; South Dakota has no state income tax. Cost of living: BEA price parity, U.S. = 100.

Medical Assistants salary in other states

Medical Assistants salary by city and state

More about pay in South Dakota

Sources and how to read this page

Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 31-9092.
U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.

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