Pharmacists Salary in South Dakota

Pharmacists in South Dakota earn the most in Sioux Falls (average $145,350 a year) and the least in Rapid City ($139,490), across the 2 South Dakota metro areas we cover. Statewide, BLS puts the pharmacists average at $142,330 and the median at $146,790 for 1,280 workers. The U.S. average for this job is $140,920.

Pharmacists average salary by city in South Dakota

Sioux Falls$145,350
Rapid City$139,490

Pay, take-home pay and cost of living

City	Average	Median	25th pct.	Take-home*	Cost of living
Sioux Falls	$145,350	$148,330	$135,680	$110,613	91
Rapid City	$139,490	$140,340	$133,540	$106,607	89

*Average salary after federal and state taxes for a single filer; South Dakota has no state income tax. Cost of living: BEA price parity, U.S. = 100.

Pharmacists salary in other states

Pharmacists salary by city and state

More about pay in South Dakota

Sources and how to read this page

Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1051.
U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.

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