Pharmacists pay range in Sioux Falls
New workers and the lowest-paid 10% earn about $123,700 a year or less, while the top 10% make $174,070 or more. The middle half of pharmacists in Sioux Falls earn between $135,680 and $162,770.
- $124K10th
- $136K25th
- $148KMedian
- $163K75th
- $174K90th
median average · bar = middle 50% of workers · how to read it
| Pay level | Per year | Per month | Per hour* |
|---|---|---|---|
| Average | $145,350 | $12,112 | $69.88 |
| Median | $148,330 | $12,361 | $71.31 |
| Entry level (25th percentile) | $135,680 | $11,307 | $65.23 |
| Experienced (75th percentile) | $162,770 | $13,564 | $78.25 |
*Hourly figures assume 2,080 paid hours a year. Hourly to annual salary.
Pharmacists pay in Sioux Falls vs. South Dakota and the U.S.
Pharmacists in Sioux Falls earn about the same as the South Dakota average ($142,330) and 3% more than the U.S. average ($140,920). At the median the gap is +5% against the U.S. median of $140,910.
| Area | Average | Median | 10th pct. | 90th pct. | Jobs |
|---|---|---|---|---|---|
| Sioux Falls | $145,350 | $148,330 | $123,700 | $174,070 | 690 |
| South Dakota | $142,330 | $146,790 | $112,200 | $166,340 | 1,280 |
| United States | $140,920 | $140,910 | $99,290 | $174,230 | 321,970 |
State and U.S. rows: BLS statewide and national estimates, May 2025, which include rural areas.
Pharmacists salary after taxes in Sioux Falls
On the average salary of $145,350, a single filer in Sioux Falls takes home about $110,613 a year, or $9,218 a month and $4,254 every two weeks. Taxes take 24% of gross pay.
The Sioux Falls, SD-MN metro area crosses state lines, so take-home pay depends on the state where you work:
| State | Per year | Per month |
|---|---|---|
| Working in SD | $110,613 | $9,218 |
| Working in MN | $102,036 | $8,503 |
Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and no state income tax.
Is Sioux Falls a good place for pharmacists? Pay vs. cost of living
Prices in the Sioux Falls area are 9% below the U.S. average (BEA price parity 90.6), so the average $145,350 buys what about $160,376 would buy in a typical U.S. metro. This job pays 3.1 times the median wage of all jobs in Sioux Falls ($47,970). A typical home costs $342,936, or 2.4 years of this average salary before tax.
Pharmacists salary in other South Dakota cities
Sioux Falls ranks 1st of 2 South Dakota metro areas for this job, the best-paid in the state.
- Sioux Falls$145,350
- Rapid City$139,490
Highest-paying cities for pharmacists
San Jose, CA pays this job the most of the metro areas we cover ($190,370).
- San Jose, CA$190,370
- Napa, CA$186,750
- San Francisco, CA$184,540
- Florence, SC$184,250
- Santa Rosa, CA$175,910
Does this match what you are paid?
Anonymous, no account. Results update as visitors answer.
Share your pay anonymously
Pharmacists salary in Sioux Falls: questions
How much do pharmacists make an hour in Sioux Falls?
$69.88 an hour on average, and $71.31 at the median (BLS, May 2025).
What is the entry-level pharmacists salary in Sioux Falls?
The lowest-paid 10% earn about $123,700 a year and the 25th percentile is $135,680, a fair guide to starting pay.
What is the pharmacists take-home pay in Sioux Falls?
About $110,613 a year ($9,218 a month) for a single filer on the average salary of $145,350. South Dakota has no state income tax.
Do pharmacists earn more in Sioux Falls than elsewhere?
The average here is 3% more than the U.S. average for this job ($140,920).
Sources and how to read this page
- Wages: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates for metropolitan areas. SOC code 29-1051; area Sioux Falls, SD-MN (43620). Relative standard error of the mean wage: 0.8%.
- U.S. and statewide figures: BLS OEWS national and state estimates, May 2025, every employer including rural areas.
- Cost of living: Bureau of Economic Analysis regional price parities (RPP), 2024; 100 = U.S. average.
- Home value: Zillow Home Value Index. Typical-wage figure: OEWS all occupations, same metro.
- Take-home pay: Single filer, standard deduction: federal income tax (2026 brackets), Social Security, Medicare and no state income tax.
- Job concentration: location quotient 1.85, this job is 1.9 times as concentrated as in the U.S. overall.
Read the full methodology. Spotted an error? Tell us.